Lack of association of PON polymorphisms with sporadic ALS in an Italian population

Claudia Ricci; Stefania Battistini; Lorena Cozzi; Michele Benigni; Paola Origone; Lorenzo Verriello; Christian Lunetta; Cristina Cereda; Pamela Milani; Giuseppe Greco; Maria Cristina Patrosso; Renzo Causarano; Claudia Caponnetto; Fabio Giannini; Massimo Corbo; Silvana Penco

doi:10.1016/j.neurobiolaging.2010.02.010

Lack of association of PON polymorphisms with sporadic ALS in an Italian population

Neurobiol Aging. 2011 Mar;32(3):552.e7-13. doi: 10.1016/j.neurobiolaging.2010.02.010. Epub 2010 Apr 9.

Authors

Claudia Ricci¹, Stefania Battistini, Lorena Cozzi, Michele Benigni, Paola Origone, Lorenzo Verriello, Christian Lunetta, Cristina Cereda, Pamela Milani, Giuseppe Greco, Maria Cristina Patrosso, Renzo Causarano, Claudia Caponnetto, Fabio Giannini, Massimo Corbo, Silvana Penco

Affiliation

¹ Department of Neuroscience-Neurology Section, University of Siena, Siena, Italy.

PMID: 20381198
DOI: 10.1016/j.neurobiolaging.2010.02.010

Abstract

Paraoxonase (PON) gene polymorphisms have been associated with susceptibility to sporadic amyotrophic lateral sclerosis (ALS). We have investigated the role of the previously associated single nucleotide polymorphisms rs854560, rs662, and rs6954345 in 350 ALS patients and 376 matched controls from Italy. No significant association was observed at genotype and haplotype level. Our data suggest that PON polymorphisms are not involved in ALS pathogenesis in an Italian population.

MeSH terms

Aged
Amyotrophic Lateral Sclerosis / genetics*
Aryldialkylphosphatase / genetics*
Chi-Square Distribution
DNA Mutational Analysis
Female
Genotype
Humans
Italy / epidemiology
Male
Middle Aged
Polymorphism, Single Nucleotide / genetics*

Substances

Aryldialkylphosphatase
PON1 protein, human