Fanconi anemia and breast cancer susceptibility meet again

Nat Genet. 2010 May;42(5):368-9. doi: 10.1038/ng0510-368.

Abstract

A new study reports biallelic mutations in RAD51C in a Fanconi anemia-like disorder, while a second study reports monoallelic mutations in the same gene associated with increased breast cancer risk. These findings strengthen the link between Fanconi anemia and breast cancer-associated pathways.

Publication types

  • Comment

MeSH terms

  • Breast Neoplasms / genetics*
  • Child
  • Cross-Linking Reagents / pharmacology
  • DNA Repair
  • DNA-Binding Proteins / genetics
  • Fanconi Anemia / genetics*
  • Female
  • Genetic Complementation Test
  • Genetic Predisposition to Disease*
  • Humans
  • Medical Oncology / methods
  • Models, Genetic
  • Mutation
  • Ovarian Neoplasms / genetics
  • Recombination, Genetic

Substances

  • Cross-Linking Reagents
  • DNA-Binding Proteins
  • RAD51C protein, human