Abstract
A new study reports biallelic mutations in RAD51C in a Fanconi anemia-like disorder, while a second study reports monoallelic mutations in the same gene associated with increased breast cancer risk. These findings strengthen the link between Fanconi anemia and breast cancer-associated pathways.
MeSH terms
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Breast Neoplasms / genetics*
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Child
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Cross-Linking Reagents / pharmacology
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DNA Repair
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DNA-Binding Proteins / genetics
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Fanconi Anemia / genetics*
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Female
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Genetic Complementation Test
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Genetic Predisposition to Disease*
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Humans
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Medical Oncology / methods
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Models, Genetic
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Mutation
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Ovarian Neoplasms / genetics
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Recombination, Genetic
Substances
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Cross-Linking Reagents
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DNA-Binding Proteins
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RAD51C protein, human