Abstract
The nonreceptor tyrosine kinase SYK has recently received a good deal of attention as a critical oncogene in various hematologic malignancies. A newly developed model of peripheral T cell lymphoma (PTCL) using the ITK-SYK fusion gene should serve as a powerful tool to dissect the signaling cascades important for SYK-associated malignancy in the context of t(5;9) PTCL.
MeSH terms
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Animals
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Chromosomes, Human, Pair 5
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Chromosomes, Human, Pair 9
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Disease Models, Animal
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Hematologic Neoplasms / genetics
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Hematologic Neoplasms / immunology
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Humans
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Intracellular Signaling Peptides and Proteins / genetics*
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Lymphoma, T-Cell, Peripheral / genetics
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Lymphoma, T-Cell, Peripheral / immunology*
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Mice
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Oncogenes
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Protein-Tyrosine Kinases / genetics*
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Recombinant Fusion Proteins / genetics
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Recombinant Fusion Proteins / metabolism
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Syk Kinase
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T-Lymphocytes / enzymology
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T-Lymphocytes / immunology
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Translocation, Genetic
Substances
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Intracellular Signaling Peptides and Proteins
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Recombinant Fusion Proteins
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Protein-Tyrosine Kinases
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SYK protein, human
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Syk Kinase
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Syk protein, mouse
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emt protein-tyrosine kinase