G546A polymorphism of growth differentiation factor-9 contributes to the poor outcome of ovarian stimulation in women with diminished ovarian reserve

Ting-Ting Wang; Yan-Ting Wu; Min-Yue Dong; Jian-Zhong Sheng; Peter C K Leung; He-Feng Huang

doi:10.1016/j.fertnstert.2010.03.070

G546A polymorphism of growth differentiation factor-9 contributes to the poor outcome of ovarian stimulation in women with diminished ovarian reserve

Fertil Steril. 2010 Nov;94(6):2490-2. doi: 10.1016/j.fertnstert.2010.03.070. Epub 2010 May 7.

Authors

Ting-Ting Wang¹, Yan-Ting Wu, Min-Yue Dong, Jian-Zhong Sheng, Peter C K Leung, He-Feng Huang

Affiliation

¹ Department of Reproductive Endocrinology, Zhejiang Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.

PMID: 20451184
DOI: 10.1016/j.fertnstert.2010.03.070

Abstract

The growth differential factor-9 (GDF-9) gene, an oocyte-specific factor, was screened in 106 Chinese women with diminished ovarian reserve (DOR), and three single-nucleotide polymorphisms, c.G169A, c.C447T and c.G546A, were detected. We found GDF-9 c.G546A, but not c.G169A or c.C447T, to be correlated with the poor ovarian stimulation and in vitro fertilization outcomes in women with DOR.

Publication types

Controlled Clinical Trial
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Cell Count
Female
Fertilization in Vitro
Genetic Predisposition to Disease
Growth Differentiation Factor 9 / genetics*
Humans
Infertility, Female / diagnosis
Infertility, Female / genetics
Infertility, Female / pathology
Infertility, Female / therapy
Mutation, Missense / physiology
Ovary / pathology
Ovulation Induction* / methods
Polymorphism, Single Nucleotide* / physiology
Pregnancy
Pregnancy Rate
Primary Ovarian Insufficiency / diagnosis*
Primary Ovarian Insufficiency / genetics*
Primary Ovarian Insufficiency / pathology
Primary Ovarian Insufficiency / therapy
Prognosis
Risk Factors
Treatment Outcome

Substances

Growth Differentiation Factor 9