5HT1A and 5HT2A receptor genes in treatment response phenotypes in major depressive disorder

Int Clin Psychopharmacol. 2010 Jul;25(4):228-31. doi: 10.1097/YIC.0b013e328338bcf4.

Abstract

The 5HT2A (5HTR2A) and 5HT1A receptor (5HTR1A) genes are plausible candidate genes for major depressive disorders. Two single nucleotide polymorphisms, the rs7997012 in 5HTR2A and the -1019C/G in 5HTR1A, were analyzed in 206 patients with Diagnostic and Statistical Manual of Mental Disorders, fourth edition major depressive disorder. Patients were retrospectively characterized for clinical response to antidepressant treatment. We found a significant difference in the rs7997012 allele frequency between resistant and nonresistant patients. However, following the Bonferroni correction we could not find any association between this single nucleotide polymorphism and treatment resistance phenotype. Nevertheless, given the limited power of our analysis, we are not able to conclude that these results reflect a lack of association. Additional studies are needed to confirm or to disprove our result.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antidepressive Agents / therapeutic use*
  • Depressive Disorder, Major / diagnosis
  • Depressive Disorder, Major / drug therapy*
  • Drug Resistance
  • Gene Frequency / genetics
  • Genotype
  • Humans
  • Pharmacogenetics
  • Phenotype
  • Polymorphism, Single Nucleotide / genetics*
  • Psychiatric Status Rating Scales
  • Receptor, Serotonin, 5-HT1A / genetics*
  • Receptor, Serotonin, 5-HT2A / genetics*
  • Remission Induction
  • Retrospective Studies
  • Treatment Outcome

Substances

  • Antidepressive Agents
  • Receptor, Serotonin, 5-HT2A
  • Receptor, Serotonin, 5-HT1A