AIP gene and familial isolated pituitary adenomas

Zehra Ozfirat; Márta Korbonits

doi:10.1016/j.mce.2010.05.001

AIP gene and familial isolated pituitary adenomas

Mol Cell Endocrinol. 2010 Sep 15;326(1-2):71-9. doi: 10.1016/j.mce.2010.05.001. Epub 2010 May 8.

Authors

Zehra Ozfirat¹, Márta Korbonits

Affiliation

¹ Department of Endocrinology, William Harvey Research Institute, Bart's and the London School of Medicine, Queen Mary University of London, Charterhouse Square, London EC1M6BQ, UK.

PMID: 20457215
DOI: 10.1016/j.mce.2010.05.001

Abstract

Familial pituitary adenomas occurr in the classical syndromes of MEN1 and Carney Complex as well as in Familial Isolated Pituitary Adenomas (FIPA), an autosomal dominant disease with incomplete penetrance. In some families and also rarely in sporadic tumours germline mutations of a gene located on chromosome 11q13 known as the aryl hydrocarbon receptor interacting protein have been found. This article discusses the AIP mutations in these groups and the different molecular interactions of AIP that may play a role in pituitary tumour formation.

Publication types

Review

MeSH terms

Adenoma / genetics*
Adenoma / metabolism
Adenoma / pathology
Animals
Cyclic AMP / metabolism
Dioxins / toxicity
GTP-Binding Proteins / metabolism
Humans
Inhibitor of Apoptosis Proteins / metabolism
Intracellular Signaling Peptides and Proteins / genetics*
Intracellular Signaling Peptides and Proteins / physiology*
Phosphoric Diester Hydrolases / metabolism
Pituitary Gland / metabolism
Pituitary Gland / pathology
Pituitary Neoplasms / genetics*
Pituitary Neoplasms / metabolism
Pituitary Neoplasms / pathology
Proto-Oncogene Proteins c-ret / metabolism
Rats

Substances

Dioxins
Inhibitor of Apoptosis Proteins
Intracellular Signaling Peptides and Proteins
aryl hydrocarbon receptor-interacting protein
Cyclic AMP
Proto-Oncogene Proteins c-ret
Phosphoric Diester Hydrolases
GTP-Binding Proteins