Association between the catechol-O-methyltransferase Val158Met polymorphism and panic disorder: a replication

Kristina Annerbrink; Lars Westberg; Marie Olsson; Christer Allgulander; Sven Andersch; Ingemar Sjödin; Göran Holm; Elias Eriksson

doi:10.1016/j.psychres.2009.11.022

Association between the catechol-O-methyltransferase Val158Met polymorphism and panic disorder: a replication

Psychiatry Res. 2010 Jun 30;178(1):196-8. doi: 10.1016/j.psychres.2009.11.022. Epub 2010 May 8.

Authors

Kristina Annerbrink¹, Lars Westberg, Marie Olsson, Christer Allgulander, Sven Andersch, Ingemar Sjödin, Göran Holm, Elias Eriksson

Affiliation

¹ Department of Pharmacology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. kristina.annerbrink@pharm.gu.se

PMID: 20457471
DOI: 10.1016/j.psychres.2009.11.022

Abstract

The association between the catechol-O-methyltransferase Val158Met polymorphism and panic disorder was studied in a Swedish sample of 211 patients and 452 controls. We found a significant excess of the Val allele in both male and female patients, the latter but not the former finding being in line with previous studies.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Catechol O-Methyltransferase / genetics*
Female
Gene Frequency
Genetic Association Studies
Humans
Male
Methionine / genetics*
Middle Aged
Panic Disorder / genetics*
Polymorphism, Genetic*
Sweden
Valine / genetics*

Substances

Methionine
Catechol O-Methyltransferase
Valine