Abstract
Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis and has been proposed to be a tumor suppressor in a variety of tumors. Limited reports exist of PEDF in colorectal cancer (CRC). We noted a 55% lower plasma level (p < .001) of PEDF in the CRC patient group (1.6 μg/mL) than in of a healthy control group (3.6 μg/mL). A single nucleotide polymorphism (rs1136287, T>C) was screened. In the control group, the CC genotype showed 30% lower PEDF plasma levels compared with the TT genotype (p < .01), whereas the CRC patients failed to show any association regarding these genotypes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Substitution
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Angiogenesis Inhibitors / genetics
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Colorectal Neoplasms / blood
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Colorectal Neoplasms / genetics*
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Colorectal Neoplasms / metabolism
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DNA, Neoplasm / genetics
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DNA, Neoplasm / isolation & purification
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Enzyme-Linked Immunosorbent Assay
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Eye Proteins / blood
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Eye Proteins / genetics*
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Eye Proteins / metabolism
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Genotype
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Humans
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Interleukin-6 / blood
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Methionine / genetics
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Nerve Growth Factors / blood
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Nerve Growth Factors / genetics*
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Nerve Growth Factors / metabolism
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Polymorphism, Single Nucleotide*
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Protease Inhibitors / blood
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Reference Values
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Serpins / blood
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Serpins / genetics*
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Serpins / metabolism
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Threonine / genetics
Substances
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Angiogenesis Inhibitors
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DNA, Neoplasm
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Eye Proteins
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Interleukin-6
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Nerve Growth Factors
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Protease Inhibitors
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Serpins
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pigment epithelium-derived factor
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Threonine
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Methionine