Abstract
Summary Among 288 HIV-1-infected, breastfeeding women who received zidovudine prophylaxis and were followed with their infants in Nairobi, we found no associations between maternal genetic polymorphisms in CCR5 (59029G/A, 59353T/C, 59356T/C, 59402G/A), RANTES (-403G/A) and SDF-1 (3'801G/A) and mother-to-child HIV-1 transmission; plasma, cervical and breastmilk viral loads; or breastmilk chemokine concentrations.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
MeSH terms
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Adolescent
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Adult
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Anti-HIV Agents / therapeutic use
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Body Fluids / virology
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Cervix Uteri / virology
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Chemokine CCL5 / analysis
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Chemokine CCL5 / genetics*
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Chemokine CXCL12 / analysis
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Chemokine CXCL12 / genetics*
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Cohort Studies
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Female
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Genetic Predisposition to Disease
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Gestational Age
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HIV Infections / congenital
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HIV Infections / drug therapy
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HIV Infections / epidemiology
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HIV Infections / genetics*
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HIV Infections / transmission*
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HIV-1* / isolation & purification
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Humans
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Infant, Newborn
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Infectious Disease Transmission, Vertical* / prevention & control
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Kenya / epidemiology
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Milk, Human / chemistry
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Milk, Human / virology
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Polymorphism, Genetic*
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Pregnancy
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Pregnancy Complications, Infectious / drug therapy
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Pregnancy Complications, Infectious / epidemiology
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Pregnancy Complications, Infectious / genetics*
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Receptors, CCR5 / genetics*
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Viral Load
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Viremia / drug therapy
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Viremia / epidemiology
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Viremia / genetics
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Young Adult
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Zidovudine / therapeutic use
Substances
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Anti-HIV Agents
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CCL5 protein, human
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CXCL12 protein, human
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Chemokine CCL5
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Chemokine CXCL12
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Receptors, CCR5
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Zidovudine