[Association of cyclic adenosine monophosphate response element-binding protein gene and major depressive disorder]

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2010 Jun;27(3):263-6. doi: 10.3760/cma.j.issn.1003-9406.2010.0.006.
[Article in Chinese]

Abstract

Objective: To investigate the association between single nucleotide polymorphisms (SNPs) in cyclic adenosine monophosphate response element-binding protein(CREB1) gene and major depressive disorder (MDD).

Methods: We recruited 105 parent-offspring trios of Chinese descent, extracted whole blood genomic DNA, and genotyped the SNPs in rs10932201 and rs6740584 loci. Single-marker transmission disequilibrium test (TDT), pairwise SNP linkage disequilibrium(LD) and haplotype-based TDT were performed.

Results: No significant association with MDD was observed for SNPs rs10932201 and rs6740584 (P=0.1004 and P=0.4986). However, there was strong positive association between the rs10932201-rs6740584 haplotype and MDD (P=0.00003241), and both haplotypes of A-C and A-T were significantly associated with MDD (P=0.020 and P=0.00022).

Conclusion: The rs10932201-rs6740584 haplotype of the CREB1 gene may play an important role in the pathogenesis of MDD.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cyclic AMP Response Element-Binding Protein / genetics*
  • Depressive Disorder, Major / genetics*
  • Female
  • Genetic Predisposition to Disease
  • Haplotypes
  • Humans
  • Male
  • Polymorphism, Single Nucleotide / genetics*

Substances

  • CREB1 protein, human
  • Cyclic AMP Response Element-Binding Protein