Positive association between GRIN2B gene and bipolar disorder in the Chinese Han Population

Qian Zhao; Ronglin Che; Zhao Zhang; Peng Wang; Jun Li; You Li; Ke Huang; Wei Tang; Guoyin Feng; Klaus Lindpaintner; Lin He; Yongyong Shi

doi:10.1016/j.psychres.2009.11.026

Positive association between GRIN2B gene and bipolar disorder in the Chinese Han Population

Psychiatry Res. 2011 Jan 30;185(1-2):290-2. doi: 10.1016/j.psychres.2009.11.026. Epub 2010 May 26.

Authors

Qian Zhao¹, Ronglin Che, Zhao Zhang, Peng Wang, Jun Li, You Li, Ke Huang, Wei Tang, Guoyin Feng, Klaus Lindpaintner, Lin He, Yongyong Shi

Affiliation

¹ Bio-X Center and affiliated Changning Mental Health Center, Shanghai Jiao Tong, University, PR China.

PMID: 20537720
DOI: 10.1016/j.psychres.2009.11.026

Abstract

In the present work we genotyped three single-nucleotide polymorphisms (SNPs) (rs7301328, rs1805247, and rs1805502) of the GRIN2B gene in a set of 480 unrelated bipolar disorder patients and 480 unrelated genetically matched normal controls in Chinese Han population by either allelic-specific multiplex ligation-detection reaction (AMLR) technology or direct sequencing. Rs1805247 and the haplotype consisting of rs1805502 and rs1805247 were significantly associated, suggesting GRIN2B as having a role in the etiology of bipolar disorder.

MeSH terms

Adult
Bipolar Disorder / genetics*
Chi-Square Distribution
China / epidemiology
China / ethnology
Female
Gene Frequency
Genetic Predisposition to Disease*
Genome-Wide Association Study
Genotype
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide / genetics*
Psychiatric Status Rating Scales
Receptors, N-Methyl-D-Aspartate / genetics*

Substances

NR2B NMDA receptor
Receptors, N-Methyl-D-Aspartate