Genetic and functional study of the IPO5 gene in schizophrenia

Zhen-Qi Wang; Yang Liu; Ning Wu; Qi Xu; Shun-Zi Jin; Gui-Zhi Ju; Lin Ye; Li-Bo Liu; Xuan Zhang; Jiang Wu

doi:10.1016/j.psychres.2010.05.010

Genetic and functional study of the IPO5 gene in schizophrenia

Psychiatry Res. 2011 May 30;187(3):460-1. doi: 10.1016/j.psychres.2010.05.010. Epub 2010 Jun 12.

Authors

Zhen-Qi Wang¹, Yang Liu, Ning Wu, Qi Xu, Shun-Zi Jin, Gui-Zhi Ju, Lin Ye, Li-Bo Liu, Xuan Zhang, Jiang Wu

Affiliation

¹ Research Center for Genomic Medicine and MH Radiobiology Research Unit, Jilin University, Changchun 130021, China.

PMID: 20542336
DOI: 10.1016/j.psychres.2010.05.010

Abstract

The present work reported on a weak association of the importin 5 (IPO5) gene with schizophrenia in combined family and case-control samples and also investigated a possible mechanism by which the IPO5 gene may contribute to the development of the disease in a Chinese population. Our results suggest that abnormal expression and alternative splicing of the IPO5 gene may be involved in the pathophysiology of schizophrenia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
China
Family Health
Female
Gene Frequency
Genetic Predisposition to Disease*
Genome-Wide Association Study
Genotype
Humans
Male
Polymorphism, Single Nucleotide / genetics*
Schizophrenia / genetics*
beta Karyopherins / genetics*

Substances

IPO5 protein, human
beta Karyopherins