Abstract
Macrophage Stimulating Protein (MSP) is the only known ligand for the receptor tyrosine kinase Ron. The MSP/Ron pathway is involved in several important biological processes, including macrophage activity, wound healing, and epithelial cell behavior. A role for MSP/Ron in breast cancer has recently been elucidated, wherein this pathway regulates tumor growth, angiogenesis, and metastasis. Here, we review the recent literature surrounding MSP/Ron function in tumor cells, inflammatory cells, and osteoclasts - cell types that often coexist in breast tumor microenvironments. We discuss the potential implications of MSP/Ron activity occurring concurrently in these cell types on tumor progression and metastasis. Lastly, we outline the potential for targeting MSP/Ron as a novel therapy for breast cancer, and for other cancer types.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Animals
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Breast Neoplasms / drug therapy*
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Breast Neoplasms / metabolism*
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Breast Neoplasms / physiopathology
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Cell Line, Tumor
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Disease Progression
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Epithelial Cells / metabolism
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Female
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Hepatocyte Growth Factor / metabolism*
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Humans
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Inflammation / physiopathology
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Macrophages / physiology
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Mice
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Mice, Transgenic
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Molecular Targeted Therapy
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Neoplasms / drug therapy
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Neoplasms / metabolism*
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Osteoclasts / metabolism
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Proto-Oncogene Proteins / metabolism*
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Receptor Protein-Tyrosine Kinases / antagonists & inhibitors
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Receptor Protein-Tyrosine Kinases / metabolism*
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Signal Transduction*
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Wound Healing
Substances
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Proto-Oncogene Proteins
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macrophage stimulating protein
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Hepatocyte Growth Factor
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RON protein
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Receptor Protein-Tyrosine Kinases