No significant association between RELN polymorphism and autism in case-control and family-based association study in Chinese Han population

Yiqun He; Guanglei Xun; Kun Xia; Zhengmao Hu; Luxian Lv; Zemin Deng; Jingping Zhao

doi:10.1016/j.psychres.2010.04.051

No significant association between RELN polymorphism and autism in case-control and family-based association study in Chinese Han population

Psychiatry Res. 2011 May 30;187(3):462-4. doi: 10.1016/j.psychres.2010.04.051. Epub 2011 Apr 7.

Authors

Yiqun He¹, Guanglei Xun, Kun Xia, Zhengmao Hu, Luxian Lv, Zemin Deng, Jingping Zhao

Affiliation

¹ Mental Health Institute of the Second Xiangya Hospital, Central South University, 139# Renmin Middle Road, Changsha, Hunan, China.

PMID: 20554015
DOI: 10.1016/j.psychres.2010.04.051

Abstract

The present study genotyped four SNPs (rs736707, rs2229864, rs362691, and rs2073559) of the Reelin gene (RELN) in 165 autistic trios, 67 sporadic autistic children and 283 healthy controls with Chinese Han pedigree. Both case-control analysis and transmission disequilibrium test (TDT) found no evidence of significant association. The results do not support previous positive findings and suggest that the four single-nucleotide polymorphisms (SNP) of RELN are unlikely to be associated with childhood autism in Chinese Han population.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Autistic Disorder / ethnology
Autistic Disorder / genetics*
Case-Control Studies
Cell Adhesion Molecules, Neuronal / genetics*
Chi-Square Distribution
China / ethnology
Extracellular Matrix Proteins / genetics*
Family Health*
Female
Gene Frequency
Genome-Wide Association Study / methods
Genotype
Humans
Male
Nerve Tissue Proteins / genetics*
Polymorphism, Genetic / genetics*
Reelin Protein
Serine Endopeptidases / genetics*
Young Adult

Substances

Cell Adhesion Molecules, Neuronal
Extracellular Matrix Proteins
Nerve Tissue Proteins
Reelin Protein
RELN protein, human
Serine Endopeptidases