The role of MSP I CYP1A1 gene polymorphism in the development of uterine fibroids

Marco Antônio Barão; Emerson Oliveira; Mariano Tamura Vieira Gomes; Ismael Dale Cotrim Guerreiro da Silva; Marair Gracio Ferreira Sartori; Manoel João Batista Castello Girão; Rodrigo de Aquino Castro

doi:10.1016/j.fertnstert.2010.05.034

The role of MSP I CYP1A1 gene polymorphism in the development of uterine fibroids

Fertil Steril. 2010 Dec;94(7):2783-5. doi: 10.1016/j.fertnstert.2010.05.034. Epub 2010 Jul 1.

Authors

Marco Antônio Barão¹, Emerson Oliveira, Mariano Tamura Vieira Gomes, Ismael Dale Cotrim Guerreiro da Silva, Marair Gracio Ferreira Sartori, Manoel João Batista Castello Girão, Rodrigo de Aquino Castro

Affiliation

¹ Department of Gynecology, Federal University of São Paulo, São Paulo, Brazil.

PMID: 20579990
DOI: 10.1016/j.fertnstert.2010.05.034

Abstract

The cytochrome P-450 1A1 (CYPA1A) gene plays an important role in the metabolization of estrogen and is therefore a candidate marker for fibroids. In a case-control study, we were unable to demonstrate any association between MSP I CYP1A1 polymorphism and the risk of leiomyoma in Brazilian women.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Brazil
Case-Control Studies
Cytochrome P-450 CYP1A1 / genetics*
Cytochrome P-450 CYP1A1 / physiology
Deoxyribonuclease HpaII* / metabolism
Estradiol / blood
Estradiol / pharmacokinetics
Female
Genetic Predisposition to Disease
Genotype
Humans
Leiomyoma / blood
Leiomyoma / genetics*
Leiomyoma / metabolism
Metabolic Clearance Rate / genetics
Middle Aged
Polymorphism, Restriction Fragment Length / genetics
Polymorphism, Restriction Fragment Length / physiology*
Risk Factors
Uterine Neoplasms / blood
Uterine Neoplasms / genetics*
Uterine Neoplasms / metabolism

Substances

Estradiol
Cytochrome P-450 CYP1A1
Deoxyribonuclease HpaII