Prospective variants screening of connexin genes in children with hearing impairment: genotype/phenotype correlation

Hum Genet. 2010 Sep;128(3):303-13. doi: 10.1007/s00439-010-0856-x. Epub 2010 Jul 1.

Abstract

The crucial role of gap junctions, which are composed of connexin (CX) protein, in auditory functions has been confirmed by numerous studies. In this study, we investigate the prevalence and phenotype/genotype correlation of connexin (CX) gene family variants in a cohort of children with nonsyndromic hearing loss (HL). A total of 253 unrelated children with nonsyndromic HL were screened for the presence of variants in 6 genes of the CX gene family. The prevalence of CX gene variants in 253 patients was 19.7% (50/253). We found the frequency of a sloping audiometric configuration was significantly higher for children with GJB2 and GJB3 variants than for those with GJB4 and GJC3 variants (Adjusted OR = 4.89, p < 0.001). Conversely, the frequency of a flat audiometric configuration was significantly higher for children with GJB4 and GJC3 variants than for those with GJB2 and GJB3 variants (adjusted OR = 7.76, p < 0.001). The relative frequencies of multiplex families was significantly higher for children with GJB3 variants than for those with GJB2, GJB4, and GJC3 variants (Adjusted OR = 11.33, p = 0.003). Our results suggest the variants of GJC3, GJB4, and GJB3 may be the common genetic risk factor, after variants of GJB2, for the development of nonsyndromic HL in Taiwan. These data can be effectively applied to direct the clinical evaluation of children with CX gene variants.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Cohort Studies
  • Connexin 26
  • Connexin 30
  • Connexin 43 / genetics
  • Connexins / genetics*
  • Female
  • Genetic Association Studies
  • Genetic Testing
  • Genetic Variation*
  • Hearing Loss / genetics*
  • Humans
  • Male
  • Multigene Family
  • Mutation
  • Nerve Tissue Proteins / genetics
  • Prospective Studies
  • Taiwan

Substances

  • Connexin 30
  • Connexin 43
  • Connexins
  • GJA1 protein, human
  • GJB2 protein, human
  • GJB6 protein, human
  • GJC3 protein, human
  • Nerve Tissue Proteins
  • Connexin 26
  • GJB3 protein, human
  • connexin 30.3