Regulation of immune cell homeostasis by type I interferons

Cytokine Growth Factor Rev. 2010 Aug;21(4):227-36. doi: 10.1016/j.cytogfr.2010.05.002. Epub 2010 Jun 2.

Abstract

Although initially identified and best characterized for their role in innate antiviral defence, type I interferons (IFN-I) are also known to have an important impact on the adaptive immune response. In part, this is linked to another long-recognised property of IFN-I, namely their ability to modify cellular proliferation and survival. Here, we review the influence of IFN-I on immune cell homeostasis, focusing on their effects on T cells and antigen-presenting cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen-Presenting Cells / immunology*
  • Antigen-Presenting Cells / metabolism
  • Antiviral Agents / immunology
  • Antiviral Agents / metabolism
  • Dendritic Cells / metabolism
  • Homeostasis / physiology*
  • Humans
  • Interferon Type I / metabolism*
  • Mice
  • Mice, Knockout
  • T-Lymphocytes / immunology*
  • T-Lymphocytes / metabolism

Substances

  • Antiviral Agents
  • Interferon Type I