Abstract
Summary In this study, three polymorphic sites in the HLA-G gene: -725C>G>T, -716T>G and 14bp(indel) were genotyped. Significant differences were found between patients and controls in the alleles and genotypes for -725C>G>T and in three-point haplotypes. We observed also a significant difference in the age of disease onset between patients positive and negative for 14bp(ins). The results suggest that single nucleotide polymorphisms in the promoter of the HLA-G gene (mainly -725C>G>T), and 14bp(indel), or some genetic marker in tight linkage disequilibrium with them are associated with multiple sclerosis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3' Untranslated Regions / genetics
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Adolescent
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Adult
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Case-Control Studies
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Exons / genetics
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Female
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Genes, MHC Class I*
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Genetic Predisposition to Disease
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Genotype
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HLA Antigens / genetics*
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HLA-G Antigens
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Histocompatibility Antigens Class I / genetics*
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Humans
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Linkage Disequilibrium
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Male
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Middle Aged
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Multiple Sclerosis / epidemiology
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Multiple Sclerosis / genetics*
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Poland / epidemiology
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Polymerase Chain Reaction
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Polymorphism, Single Nucleotide*
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Promoter Regions, Genetic / genetics
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Severity of Illness Index
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Young Adult
Substances
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3' Untranslated Regions
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HLA Antigens
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HLA-G Antigens
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Histocompatibility Antigens Class I