Sequence variation analysis of the prolactin receptor C-terminal region in women with premature ovarian failure

Anne Bachelot; Justine Bouilly; Yuchen Liu; Diane Rebourcet; Céline Leux; Frédérique Kuttenn; Philippe Touraine; Nadine Binart

doi:10.1016/j.fertnstert.2010.06.040

Sequence variation analysis of the prolactin receptor C-terminal region in women with premature ovarian failure

Fertil Steril. 2010 Dec;94(7):2772-5. doi: 10.1016/j.fertnstert.2010.06.040. Epub 2010 Jul 24.

Authors

Anne Bachelot¹, Justine Bouilly, Yuchen Liu, Diane Rebourcet, Céline Leux, Frédérique Kuttenn, Philippe Touraine, Nadine Binart

Affiliation

¹ Institut National de la Santé et de la Recherche Médicale, U845, Paris, France.

PMID: 20655519
DOI: 10.1016/j.fertnstert.2010.06.040

Abstract

Using a mouse model expressing only the PRL receptor short isoform mimicking premature ovarian failure, signaling pathways induced by PRL were analyzed in mouse ovaries. Sequencing of the coding portion of exons 10 and 11, specific to the long and short receptor isoform, respectively, did not revealed any mutation in 101 women with premature ovarian failure.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Animals
Base Sequence
Cell Count
DNA Mutational Analysis
Female
Genetic Variation
Humans
Male
Mice
Mice, Transgenic
Oocytes / cytology
Oocytes / pathology
Primary Ovarian Insufficiency / genetics*
Primary Ovarian Insufficiency / pathology
Protein Isoforms / chemistry
Protein Isoforms / genetics
Protein Structure, Tertiary / genetics
Receptors, Prolactin / chemistry
Receptors, Prolactin / genetics*

Substances

Protein Isoforms
Receptors, Prolactin