Beta3-adrenergic receptor polymorphism is related to cardiometabolic risk factors in obese Brazilian subjects

V A Genelhu; E A Francischetti; S F P Duarte; B M J Celoria; R C Oliveira; P H Cabello; M M G Pimentel

doi:10.4238/vol9-3gmr819

Beta3-adrenergic receptor polymorphism is related to cardiometabolic risk factors in obese Brazilian subjects

Genet Mol Res. 2010;9(3):1392-7. doi: 10.4238/vol9-3gmr819.

Authors

V A Genelhu¹, E A Francischetti, S F P Duarte, B M J Celoria, R C Oliveira, P H Cabello, M M G Pimentel

Affiliation

¹ Laboratório de Fisiopatologia Clínica e Experimental (CLINEX), Clínica de Hipertensão, Faculdade de Ciências Médicas, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brasil.

PMID: 20662153
DOI: 10.4238/vol9-3gmr819

Abstract

We determined whether ADRbeta3 polymorphism is associated with obesity-related traits in 140 obese patients. Molecular analysis was performed by PCR and RFLP. Individuals carrying the Arg64 allele had a lower waist-to-hip ratio, higher adiponectin and high-density lipoprotein cholesterol levels, and a tendency towards lower blood pressure. In contrast, Trp64/Trp64 carriers were at greater risk for dysmetabolic phenotypes (odds ratio = 2.88, P = 0.03).

MeSH terms

Adolescent
Adult
Aged
Amino Acid Substitution / genetics
Brazil
Cardiovascular Diseases / complications*
Cardiovascular Diseases / genetics
Female
Genetic Predisposition to Disease*
Humans
Logistic Models
Male
Metabolic Syndrome / complications*
Metabolic Syndrome / genetics
Middle Aged
Obesity / complications*
Obesity / genetics
Polymorphism, Single Nucleotide / genetics*
Receptors, Adrenergic, beta-3 / genetics*
Risk Factors
Young Adult

Substances

Receptors, Adrenergic, beta-3