MUTYH-associated polyposis (MAP)

Maartje Nielsen; Hans Morreau; Hans F A Vasen; Frederik J Hes

doi:10.1016/j.critrevonc.2010.05.011

MUTYH-associated polyposis (MAP)

Crit Rev Oncol Hematol. 2011 Jul;79(1):1-16. doi: 10.1016/j.critrevonc.2010.05.011. Epub 2010 Jul 21.

Authors

Maartje Nielsen¹, Hans Morreau, Hans F A Vasen, Frederik J Hes

Affiliation

¹ Department Clinical Genetics, Leiden University Medical Centre, Albinusdreef, Leiden, The Netherlands. m.nielsen@lumc.nl

PMID: 20663686
DOI: 10.1016/j.critrevonc.2010.05.011

Abstract

The human mutY homologue (MUTYH) gene is responsible for inheritable polyposis and colorectal cancer. This review discusses the molecular genetic aspects of the MUTYH gene and protein, the clinical impact of mono- and biallelic MUTYH mutations and histological aspects of the MUTYH tumors. Furthermore, the relationship between MUTYH and the mismatch repair genes in colorectal cancer (CRC) families is examined. Finally, the role of other base excision repair genes in polyposis and CRC patients is discussed.

Publication types

Review

MeSH terms

Adenomatous Polyposis Coli / genetics*
Colorectal Neoplasms / genetics*
DNA Glycosylases / genetics*
Humans
Mutation

Substances

DNA Glycosylases
mutY adenine glycosylase