Background and objective: The relationship between myeloperoxidase G-463A genetic polymorphisms and lung cancer susceptibility has been studied extensively. However, the outcomes are not consistent. The aim of this study is to evaluate the relationship between myeloperoxidase genetic polymorphisms and lung cancer susceptibility by meta analysis.
Methods: Documents published were retrieved through databases associated with the study. Taking into account the possibilities of heterogeneity of the studies, a statistical test for heterngeneity was performed. The odds ratio and 95% CI were used to evaluate the risks. The meta analysis was applied with RevMan software 4.2, and the forest plot and funnel plot of meta analysis were worked out.
Results: A total of 5 381 cases and 5 827 controls from studies for Caucasian and a total of 1 558 cases and 1 755 controls from studies for East Asians were included. For Caucasian the pooled OR was 0.91 (95% CI: 0.81-1.02); For East Asians, the pooled OR is 0.83 (95% CI: 0.63-1.09). Publication bias exits in the study for Caucasian, but not for East Asians.
Conclusion: The results of this study indicated that the polymorphism of myeloperoxidase G-463A was not significantly associated with the lung cancer risk for Caucasian or East Asians. However, further studies for the East Asians is needed for the few subjects.
背景与目的: 关于髓过氧化物酶基因G-463A多态性与肺癌易感性关系已有广泛研究, 但研究结果不一致。本研究利用meta分析的方法探讨髓过氧化物酶基因G-463A多态性与肺癌易感性的相关性。
方法: 全面检索公开发表的关于髓过氧化物酶基因G-463A多态性与肺癌易感性关系的研究, 把研究人群分为高加索人群和东亚人群, 以病例组与对照组比值比(odds ratio, OR)为效应指标, 应用meta分析软件RevMan 4.2分别计算两种人群的合并OR值及95%CI, 同时给出meta分析森林图和倒漏斗图。
结果: 纳入文献研究20篇, 其中高加索人群研究纳入病例5 381例, 对照5 827例; 东亚人群研究纳入病例1 558例, 对照1 755例。计算高加索人群及东亚人群髓过氧化物酶基因-463位点AA+AG/GG合并OR值, 分别为0.91(95%CI:0.81-1.02)、0.83(95%CI:0.63-1.09), 高加索人群有发表偏倚, 东亚人群没有发表偏倚。
结论: 髓过氧化物酶基因G-463A多态性与肺癌易感性在高加索人群及东亚人群均不具有明显相关性, 东亚人群研究样本量少, 有待进一步研究。