Abstract
Interleukin-2 (IL-2) has been implicated as being necessary for the optimal formation of primary CD8(+) T cell responses against various pathogens. Here we have examined the role that IL-2 signaling plays in several aspects of a CD8(+) T cell response against murine gammaherpesvirus 68 (MHV-68). Exposure to MHV-68 causes a persistent infection, along with infectious mononucleosis, providing a model for studying these processes in mice. Our study indicates that CD25 is necessary for optimal expansion of the antigen-specific CD8(+) T cell response but not for the long-term memory response. Contrastingly, IL-2 signaling through CD25 is absolutely required for CD8(+) T cell mononucleosis.
Publication types
-
Research Support, N.I.H., Extramural
MeSH terms
-
Animals
-
Antigens, Viral
-
CD8-Positive T-Lymphocytes / immunology
-
CD8-Positive T-Lymphocytes / virology
-
Disease Models, Animal
-
Herpesviridae Infections / immunology*
-
Herpesviridae Infections / virology
-
Humans
-
Infectious Mononucleosis / immunology
-
Infectious Mononucleosis / virology
-
Interleukin-2 / immunology*
-
Interleukin-2 Receptor alpha Subunit / deficiency
-
Interleukin-2 Receptor alpha Subunit / genetics
-
Mice
-
Mice, Congenic
-
Mice, Inbred C57BL
-
Mice, Knockout
-
Rhadinovirus* / immunology
-
Signal Transduction / immunology
-
Tumor Virus Infections / immunology*
-
Tumor Virus Infections / virology
Substances
-
Antigens, Viral
-
Il2ra protein, mouse
-
Interleukin-2
-
Interleukin-2 Receptor alpha Subunit