Abstract
Polymorphism of TP53 Arg72Pro is associated with many different cancers[1-4]. Few studies have investigated its role in the susceptibility to non-Hodgkin lymphoma (NHL) [5,6]. To examine the association between this polymorphism and NHL risk, we conducted a Korean large-scale, population-based case-control study (945 cases and 1,700 controls). The TP53 72CC genotype was associated with increased risk of NHL (P 5 0.04) and diffuse large B-cell lymphoma (P 5 0.04). Our findings provide evidence that the TP53 Arg72Pro is associated with an increased risk of NHL in Korea.
Publication types
-
Letter
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adolescent
-
Adult
-
Aged
-
Aged, 80 and over
-
Codon / genetics
-
Female
-
Gene Frequency
-
Genes, p53*
-
Genetic Predisposition to Disease
-
Genotype
-
Humans
-
Lymphoma, Large B-Cell, Diffuse / epidemiology
-
Lymphoma, Large B-Cell, Diffuse / genetics
-
Lymphoma, Non-Hodgkin / epidemiology
-
Lymphoma, Non-Hodgkin / genetics*
-
Male
-
Middle Aged
-
Polymorphism, Single Nucleotide*
-
Republic of Korea / epidemiology
-
Risk
-
Tumor Suppressor Protein p53 / genetics*
-
Young Adult
Substances
-
Codon
-
TP53 protein, human
-
Tumor Suppressor Protein p53