Association with TP53 codon 72 polymorphism and the risk of non-Hodgkin lymphoma

Am J Hematol. 2010 Oct;85(10):822-4. doi: 10.1002/ajh.21834.

Abstract

Polymorphism of TP53 Arg72Pro is associated with many different cancers[1-4]. Few studies have investigated its role in the susceptibility to non-Hodgkin lymphoma (NHL) [5,6]. To examine the association between this polymorphism and NHL risk, we conducted a Korean large-scale, population-based case-control study (945 cases and 1,700 controls). The TP53 72CC genotype was associated with increased risk of NHL (P 5 0.04) and diffuse large B-cell lymphoma (P 5 0.04). Our findings provide evidence that the TP53 Arg72Pro is associated with an increased risk of NHL in Korea.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Codon / genetics
  • Female
  • Gene Frequency
  • Genes, p53*
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Lymphoma, Large B-Cell, Diffuse / epidemiology
  • Lymphoma, Large B-Cell, Diffuse / genetics
  • Lymphoma, Non-Hodgkin / epidemiology
  • Lymphoma, Non-Hodgkin / genetics*
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Republic of Korea / epidemiology
  • Risk
  • Tumor Suppressor Protein p53 / genetics*
  • Young Adult

Substances

  • Codon
  • TP53 protein, human
  • Tumor Suppressor Protein p53