Endometriosis and autoimmune disease: association of susceptibility to moderate/severe endometriosis with CCL21 and HLA-DRB1

Johanna Sundqvist; Henrik Falconer; Maria Seddighzadeh; Alexandra Vodolazkaia; Amelie Fassbender; Cleophas Kyama; Attila Bokor; Olof Stephansson; Leonid Padyukov; Kristina Gemzell-Danielsson; Thomas M D'Hooghe

doi:10.1016/j.fertnstert.2010.07.1060

Endometriosis and autoimmune disease: association of susceptibility to moderate/severe endometriosis with CCL21 and HLA-DRB1

Fertil Steril. 2011 Jan;95(1):437-40. doi: 10.1016/j.fertnstert.2010.07.1060. Epub 2010 Aug 24.

Authors

Johanna Sundqvist¹, Henrik Falconer, Maria Seddighzadeh, Alexandra Vodolazkaia, Amelie Fassbender, Cleophas Kyama, Attila Bokor, Olof Stephansson, Leonid Padyukov, Kristina Gemzell-Danielsson, Thomas M D'Hooghe

Affiliation

¹ Department of Women's and Children's Health, Division of Obstetrics and Gynecology, Karolinska Institutet/Karolinska University Hospital, Stockholm, Sweden.

PMID: 20797713
DOI: 10.1016/j.fertnstert.2010.07.1060

Abstract

This study investigates the association of rheumatoid arthritis-associated single nucleotide polymorphisms in endometriosis. We found an association of CCL21 (rs2812378) and HLA-DRB1 (rs660895) with moderate to severe endometriosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Autoimmune Diseases* / epidemiology
Autoimmune Diseases* / genetics
Autoimmune Diseases* / immunology
Chemokine CCL21 / genetics*
Endometriosis* / epidemiology
Endometriosis* / genetics
Endometriosis* / immunology
Female
Genetic Predisposition to Disease / epidemiology
HLA-DR Antigens / genetics*
HLA-DRB1 Chains
Humans
Polymorphism, Single Nucleotide
Severity of Illness Index

Substances

CCL21 protein, human
Chemokine CCL21
HLA-DR Antigens
HLA-DRB1 Chains