A mutant single nucleotide polymorphism of follicle-stimulating hormone receptor is associated with a lower risk of endometriosis

Hsin-Shih Wang; Bi-Hwa Cheng; Hsien-Ming Wu; Chih-Feng Yen; Chun-Ting Liu; Angel Chao; Tzu-Hao Wang

doi:10.1016/j.fertnstert.2010.07.1092

A mutant single nucleotide polymorphism of follicle-stimulating hormone receptor is associated with a lower risk of endometriosis

Fertil Steril. 2011 Jan;95(1):455-7. doi: 10.1016/j.fertnstert.2010.07.1092.

Authors

Hsin-Shih Wang¹, Bi-Hwa Cheng, Hsien-Ming Wu, Chih-Feng Yen, Chun-Ting Liu, Angel Chao, Tzu-Hao Wang

Affiliation

¹ Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Lin-Kou Medical Center, Graduate Institute of Clinical Medical Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

PMID: 20817169
DOI: 10.1016/j.fertnstert.2010.07.1092

Abstract

Six hundred thirty-seven Taiwanese Chinese women including 300 patients with endometriosis and 337 controls without endometriosis were enrolled to investigate the association between nonsynonymous single nucleotide polymorphism of the FSH receptor gene and the risk of endometriosis. For the A/G polymorphism of FSH receptor gene (Asn680Ser), a univariate analysis for women with endometriosis demonstrated that both the GG genotype (680Ser/Ser) and GA genotype (680Ser/Asn) were associated with a significantly lower risk of endometriosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Asian People / genetics
Asian People / statistics & numerical data
Endometriosis / epidemiology*
Endometriosis / genetics*
Female
Genetic Predisposition to Disease / epidemiology
Genotype
Humans
Middle Aged
Polymorphism, Single Nucleotide*
Receptors, FSH / genetics*
Risk Factors
Taiwan / epidemiology

Substances

Receptors, FSH