Abstract
Mycobacterium tuberculosis isolates with a region of difference 105 (RD105) deletion, mainly Beijing family spoligotypes, were phylogenetically grouped into the East Asia lineage. We identified a single nucleotide polymorphism in codon 507, ATC to ATT, of the fadD28 gene as a robust marker and developed a rapid assay for East Asia lineage M. tuberculosis.
Publication types
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Evaluation Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Bacteriological Techniques / methods*
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Carbon-Sulfur Ligases / genetics*
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Cluster Analysis
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DNA, Bacterial / chemistry
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DNA, Bacterial / genetics
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Humans
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Molecular Epidemiology / methods
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Molecular Sequence Data
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Mycobacterium tuberculosis / classification*
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Mycobacterium tuberculosis / genetics*
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Mycobacterium tuberculosis / isolation & purification
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Phylogeny
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Polymorphism, Single Nucleotide*
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Sequence Analysis, DNA
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Tuberculosis / diagnosis*
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Tuberculosis / microbiology*
Substances
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DNA, Bacterial
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Carbon-Sulfur Ligases
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FadD28 protein, Mycobacterium tuberculosis