CD44: a cancer stem cell-related biomarker with predictive potential for radiotherapy

Michael Baumann; Mechthild Krause

doi:10.1158/1078-0432.CCR-10-2244

CD44: a cancer stem cell-related biomarker with predictive potential for radiotherapy

Clin Cancer Res. 2010 Nov 1;16(21):5091-3. doi: 10.1158/1078-0432.CCR-10-2244. Epub 2010 Sep 22.

Authors

Michael Baumann¹, Mechthild Krause

Affiliation

¹ Department of Radiation Oncology and OncoRay Center for Radiation Research in Oncology, Medical Faculty and University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany. Michael.Baumann@uniklinikum-dresden.de

PMID: 20861165
DOI: 10.1158/1078-0432.CCR-10-2244

Abstract

CD44, a cancer stem cell (CSC)-related surface marker, correlates with local control after radiotherapy of early laryngeal cancer. For the first time, a CSC-related marker has been functionally validated for radiotherapy in patients. CD44 expression bears the potential to predict the outcome of radiotherapy by assessment of CSC density.

Publication types

Comment

MeSH terms

Biomarkers, Tumor / genetics
Biomarkers, Tumor / metabolism
Biomarkers, Tumor / physiology
Carcinoma, Squamous Cell / diagnosis*
Carcinoma, Squamous Cell / genetics
Carcinoma, Squamous Cell / metabolism
Carcinoma, Squamous Cell / radiotherapy*
Gene Expression Regulation, Neoplastic / radiation effects
Head and Neck Neoplasms / diagnosis*
Head and Neck Neoplasms / genetics
Head and Neck Neoplasms / metabolism
Head and Neck Neoplasms / radiotherapy*
Humans
Hyaluronan Receptors / genetics
Hyaluronan Receptors / metabolism
Hyaluronan Receptors / physiology*
Models, Biological
Neoplastic Stem Cells / metabolism*
Neoplastic Stem Cells / radiation effects
Prognosis

Substances

Biomarkers, Tumor
Hyaluronan Receptors