Thyroglobulin gene is associated with premature ovarian failure

Fertil Steril. 2011 Jan;95(1):397-400. doi: 10.1016/j.fertnstert.2010.08.038. Epub 2010 Sep 22.

Abstract

Variants of the thyroglobulin gene were significantly associated with premature ovarian failure in a Korean population. Three single nucleotide polymorphisms and one haplotype were found to be associated with a significant increase in the risk for premature ovarian failure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Asian People / genetics
  • Female
  • Gene Frequency
  • Haplotypes
  • Humans
  • Hypothyroidism / epidemiology*
  • Hypothyroidism / genetics*
  • Polymorphism, Single Nucleotide
  • Primary Ovarian Insufficiency / epidemiology*
  • Primary Ovarian Insufficiency / genetics*
  • Risk Factors
  • Thyroglobulin / genetics*

Substances

  • Thyroglobulin