Upper urinary tract infections are associated with RANTES promoter polymorphism

Sonia Centi; Susanna Negrisolo; Alejandra Stefanic; Elisa Benetti; Walburga Cassar; Liviana Da Dalt; Waifro Rigamonti; Pietro Zucchetta; Giovanni Montini; Luisa Murer; Lina Artifoni

doi:10.1016/j.jpeds.2010.08.006

Upper urinary tract infections are associated with RANTES promoter polymorphism

J Pediatr. 2010 Dec;157(6):1038-1040.e1. doi: 10.1016/j.jpeds.2010.08.006. Epub 2010 Sep 24.

Authors

Sonia Centi¹, Susanna Negrisolo, Alejandra Stefanic, Elisa Benetti, Walburga Cassar, Liviana Da Dalt, Waifro Rigamonti, Pietro Zucchetta, Giovanni Montini, Luisa Murer, Lina Artifoni

Affiliation

¹ Laboratory of Immunopathology and Molecular Biology of the Kidney, Department of Pediatrics Salus Pueri, University of Padua, Italy.

PMID: 20869067
DOI: 10.1016/j.jpeds.2010.08.006

Abstract

We evaluated the association between MCP-1, CCR2, RANTES, and CCR5 gene polymorphisms and upper urinary tract infection in 273 children recruited in Northeast Italy. Statistical analysis of RANTES-403 G>A genotype frequencies showed that children carrying the RANTES-403 G allele are at higher risk for urinary tract infection, irrespective of vesicoureteral reflux.

MeSH terms

Chemokine CCL5 / genetics*
Female
Humans
Infant
Male
Polymorphism, Genetic*
Promoter Regions, Genetic / genetics*
Urinary Tract Infections / genetics*

Substances

CCL5 protein, human
Chemokine CCL5