Clinical application of therapies targeting VEGF

Cell. 2010 Oct 1;143(1):13-6. doi: 10.1016/j.cell.2010.09.028.

Abstract

This year's Lasker DeBakey Clinical Research Award goes to Napoleone Ferrara for the discovery of vascular endothelial growth factor (VEGF) as a major mediator of angiogenesis and for the development of an effective anti-VEGF therapy for wet macular degeneration, a leading cause of blindness in the elderly.

Publication types

  • Biography
  • Historical Article

MeSH terms

  • Aged
  • Angiogenesis Inhibitors / history*
  • Angiogenesis Inhibitors / therapeutic use*
  • Awards and Prizes*
  • Eye / blood supply
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Neoplasms / drug therapy
  • Neovascularization, Pathologic / prevention & control
  • United States
  • Vascular Endothelial Growth Factor A / antagonists & inhibitors*
  • Vascular Endothelial Growth Factor A / genetics
  • Wet Macular Degeneration / drug therapy*

Substances

  • Angiogenesis Inhibitors
  • Vascular Endothelial Growth Factor A

Personal name as subject

  • Napoleone Ferrara