Abstract
Chromosomal translocations in hematological malignancies often result in novel fusion chimeric genes. We report a case of acute myeloid leukemia with a clonal translocation t(11;12)(p15;q13) displaying morphologic and immunophenotypic features resembling the classical hypergranular subtype of acute promyelocytic leukemia. The gene fused to NUP98 (nucleoporin 98) was detected by comparative genomic hybridization array as the retinoid acid receptor gamma gene (RARG). The involvement of RARG in a chimeric fusion transcript has not been reported previously in human leukemia.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Chromosomes, Human, Pair 11 / genetics
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Chromosomes, Human, Pair 12 / genetics
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Comparative Genomic Hybridization
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Diagnosis, Differential
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Gene Fusion*
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Humans
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Immunophenotyping
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Leukemia, Myeloid, Acute / diagnosis
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Leukemia, Myeloid, Acute / genetics*
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Leukemia, Promyelocytic, Acute / diagnosis
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Leukemia, Promyelocytic, Acute / genetics*
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Male
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Nuclear Pore Complex Proteins / genetics*
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Oligonucleotide Array Sequence Analysis
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Oncogene Proteins, Fusion / genetics*
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Receptors, Retinoic Acid / genetics*
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Retinoic Acid Receptor gamma
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Translocation, Genetic
Substances
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Nuclear Pore Complex Proteins
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Nup98 protein, human
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Oncogene Proteins, Fusion
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Receptors, Retinoic Acid