Increased risk for acute lymphoblastic leukemia in children with cytochrome P450A1 (CYP1A1)- and NAD(P)H:quinone oxidoreductase 1 (NQO1)-inherited gene variants

Acta Haematol. 2010;124(3):182-4. doi: 10.1159/000320275. Epub 2010 Oct 20.

Authors

Gabriela G Yamaguti¹, Gustavo J Lourenço, Vanessa S Silveira, Luiz G Tone, Luiz F Lopes, Carmen S P Lima

Affiliation

¹ Clinical Oncology Service, Department of Internal Medicine, Faculty of Medical Sciences, State University of Campinas, Campinas, Brazil.

PMID: 20962519
DOI: 10.1159/000320275

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Brazil
Case-Control Studies
Child, Preschool
Cytochrome P-450 CYP1A1 / genetics*
Environmental Pollutants / metabolism
Environmental Pollutants / toxicity
Female
Gene Frequency
Genetic Predisposition to Disease
Genetic Variation
Genotype
Humans
Inactivation, Metabolic / genetics
Inactivation, Metabolic / physiology
Infant
Male
Middle Aged
NAD(P)H Dehydrogenase (Quinone) / genetics*
Polycyclic Aromatic Hydrocarbons / metabolism
Polycyclic Aromatic Hydrocarbons / toxicity
Polymorphism, Single Nucleotide
Precursor Cell Lymphoblastic Leukemia-Lymphoma / enzymology*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / etiology
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Risk Factors

Substances

Environmental Pollutants
Polycyclic Aromatic Hydrocarbons
Cytochrome P-450 CYP1A1
NAD(P)H Dehydrogenase (Quinone)
NQO1 protein, human