The expression pattern of a global set of Hsps in the adult rat cerebral cortex was examined during the first week following pilocarpine-induced status epilepticus (SE). Hsp70 and Hsp32 protein were induced at 1 day post-SE and decreased thereafter, whereas Hsp25 exhibited a prolonged induction with increased levels at 3 and 7 days post-SE. Hsp70 was induced in neurons, while Hsp25 and Hsp32 localized to GFAP-positive hypertrophied astrocytes. The induction of Hsp25, Hsp32 and Hsp70 at 1 day following SE suggests the involvement of these Hsps in early events after SE. Interestingly, while Hsp32 and Hsp70 expression was transient, Hsp25 demonstrated a sustained induction pattern, which may reflect an additional role of Hsp25 in subsequent remodeling events in the days following SE.
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