PAFc, a key player in MLL-rearranged leukemogenesis

Oncotarget. 2010 Oct;1(6):461-5. doi: 10.18632/oncotarget.181.

Abstract

Recent studies identified an interaction between the Polymerase Associated Factor complex (PAFc) and Mixed Lineage Leukemia (MLL), including MLL-rearranged oncoproteins. This interaction is critical for MLL transcriptional activity and MLL-rearranged leukemogenesis. Here, we discuss the potential molecular role of the PAFc in transcriptional dysregulation of MLL target genes and the interplay between PAFc and MLL-rearranged oncoproteins in leukemogenesis.

Keywords: leukemia; oncoprotein; oncotarget; transcription.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Gene Rearrangement*
  • Humans
  • Leukemia / genetics*
  • Leukemia / metabolism
  • Leukemia / pathology
  • Myeloid-Lymphoid Leukemia Protein / genetics*
  • Myeloid-Lymphoid Leukemia Protein / metabolism
  • Nuclear Proteins / physiology*
  • Transcription Factors

Substances

  • Nuclear Proteins
  • PAF1 protein, human
  • Transcription Factors
  • Myeloid-Lymphoid Leukemia Protein