Polymorphisms in folate-metabolizing genes and risk of non-Hodgkin's lymphoma

Alexandra S Weiner; Olga V Beresina; Elena N Voronina; Elena N Voropaeva; Uljana A Boyarskih; Tatiana I Pospelova; Maxim L Filipenko

doi:10.1016/j.leukres.2010.10.004

Polymorphisms in folate-metabolizing genes and risk of non-Hodgkin's lymphoma

Leuk Res. 2011 Apr;35(4):508-15. doi: 10.1016/j.leukres.2010.10.004. Epub 2010 Nov 4.

Authors

Alexandra S Weiner¹, Olga V Beresina, Elena N Voronina, Elena N Voropaeva, Uljana A Boyarskih, Tatiana I Pospelova, Maxim L Filipenko

Affiliation

¹ Institute of Chemical Biology and Fundamental Medicine, Novosibirsk, Russia.

PMID: 21055808
DOI: 10.1016/j.leukres.2010.10.004

Abstract

We investigated the role of single nucleotide polymorphisms (SNPs) in the folate-metabolizing genes MTHFR, MTR, MTRR, MTHFD, CBS and SHMT in regulating genetic susceptibility to Non-Hodgkin's lymphoma (NHL). We determined the allele and genotype frequencies in the case group (146 patients with NHL) and the control group (540 blood donors). A significant association with NHL was observed only for MTHFD1 G1958A (allele G OR=1.382, P=0.05; genotype GA OR=2.316, P=0.01; genotype GG OR=2.153, P=0.03). After additional stratification of case and control groups according to sex and tumor type association of MTHFD1 G1958A with NHL was observed only in high-grade NHL subgroup (allele G OR=1.664, P=0.01) and in women subgroup (allele G OR=2.043, P=0.009). Meta-analysis for SNPs in the MTHFR, MTR, MTRR and SHMT revealed a reducing effect of the MTR 2756G allele on the risk of NHL (OR=0.902; 95% CI 0.821-0.991, P=0.03).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / genetics
Adolescent
Adult
Aged
Alleles
Cystathionine beta-Synthase / genetics
Female
Ferredoxin-NADP Reductase / genetics
Folic Acid / metabolism*
Gene Frequency
Genotype
Glycine Hydroxymethyltransferase / genetics
Humans
Linkage Disequilibrium
Lymphoma, Non-Hodgkin / genetics*
Lymphoma, Non-Hodgkin / metabolism
Male
Meta-Analysis as Topic
Metabolic Networks and Pathways / genetics*
Methylenetetrahydrofolate Dehydrogenase (NADP) / genetics
Methylenetetrahydrofolate Reductase (NADPH2) / genetics
Middle Aged
Minor Histocompatibility Antigens
Odds Ratio
Polymorphism, Single Nucleotide*
Risk Factors
Young Adult

Substances

Minor Histocompatibility Antigens
Folic Acid
methionine synthase reductase
Ferredoxin-NADP Reductase
Methylenetetrahydrofolate Reductase (NADPH2)
MTHFD1 protein, human
Methylenetetrahydrofolate Dehydrogenase (NADP)
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Glycine Hydroxymethyltransferase
SHMT protein, human
Cystathionine beta-Synthase