Abstract
Ischemic stroke, white matter hyperintensities related to small vessel ischemia, and intracranial aneurysms all show heritability. This review focuses on recent progress in understanding the molecular genetics of these disorders. Also reviewed is recent progress in understanding single-gene disorders in which stroke is a major feature of the phenotype, including CADASIL, CARASIL, hereditary angiopathy with nephropathy, aneurysm and muscle cramps, and Fabry disease and progress in pharmacogenomics as it relates to response to antiplatelet therapy.
Publication types
-
Research Support, N.I.H., Extramural
-
Review
MeSH terms
-
Brain Ischemia / etiology
-
Brain Ischemia / genetics*
-
Cyclic Nucleotide Phosphodiesterases, Type 3 / genetics
-
Cyclic Nucleotide Phosphodiesterases, Type 4
-
Genetic Predisposition to Disease
-
Genome-Wide Association Study
-
Humans
-
Intracranial Aneurysm / complications
-
Risk Factors
-
Stroke / etiology
-
Stroke / genetics*
-
Vascular Diseases / complications
-
Vascular Diseases / genetics
Substances
-
Cyclic Nucleotide Phosphodiesterases, Type 3
-
Cyclic Nucleotide Phosphodiesterases, Type 4
-
PDE4D protein, human