Abstract
Recent progress in skeletal molecular biology has led to the clarification of the transcriptional mechanisms of chondroblastic and osteoblastic lineage differentiation. Three master transcription factors-Sox9, Runx2, and Osterix-were shown to play an essential role in determining the skeletal progenitor cells' fate. The present study evaluates the expression of these factors in 4 types of benign bone tumors-chondromyxoid fibroma, chondroblastoma, osteoid osteoma, and osteoblastoma-using immunohistochemistry and tissue microarrays. Osteoid osteoma and osteoblastoma showed strong nuclear expression of Osterix and Runx2. In contrast, only a few chondroblastomas showed positive nuclear expression of Osterix. Strong nuclear expression of Sox9 was detected in all chondroblastomas, whereas nearly half of the osteoblastomas showed focal weak cytoplasmic expression of Sox9.
Copyright © 2010 Elsevier Inc. All rights reserved.
MeSH terms
-
Adolescent
-
Adult
-
Aged
-
Bone Neoplasms / genetics*
-
Bone Neoplasms / pathology
-
Cartilage / growth & development*
-
Cartilage / pathology
-
Child
-
Chondroblastoma / genetics
-
Chondroblastoma / metabolism
-
Chondroblastoma / pathology
-
Chondroma / genetics
-
Chondroma / metabolism
-
Chondroma / pathology
-
Core Binding Factor Alpha 1 Subunit / genetics
-
Core Binding Factor Alpha 1 Subunit / metabolism
-
Female
-
Fibroma / genetics
-
Fibroma / metabolism
-
Fibroma / pathology
-
Gene Expression Regulation
-
Gene Regulatory Networks*
-
Humans
-
Male
-
Middle Aged
-
Neoplasms, Connective Tissue / genetics*
-
Neoplasms, Connective Tissue / metabolism
-
Neoplasms, Connective Tissue / pathology
-
Osteoblastoma / genetics
-
Osteoblastoma / metabolism
-
Osteoblastoma / pathology
-
Osteogenesis / genetics*
-
Osteoma, Osteoid / genetics
-
Osteoma, Osteoid / metabolism
-
Osteoma, Osteoid / pathology
-
SOX9 Transcription Factor / genetics
-
SOX9 Transcription Factor / metabolism
-
Sp7 Transcription Factor
-
Stem Cells / metabolism
-
Stem Cells / pathology
-
Tissue Array Analysis
-
Transcription Factors / genetics*
-
Transcription Factors / metabolism
-
Young Adult
Substances
-
Core Binding Factor Alpha 1 Subunit
-
RUNX2 protein, human
-
SOX9 Transcription Factor
-
SOX9 protein, human
-
Sp7 Transcription Factor
-
SP7 protein, human
-
Transcription Factors