Abstract
Despite recent advances in treatment of head and neck cancer, survival has not improved as expected. Bcl-2 family proteins play important role in regulating apoptosis. Recently, newer molecules have been developed for inhibition of Bcl-2 related proteins. We, herein aim to discuss the importance of Bcl-2 family proteins to the development of head and neck cancer and how the targeted-therapy for inhibition of Bcl-2 and related proteins, based on new drugs and recent patents, could improve the efficacy of the systemic therapy.
MeSH terms
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Animals
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / therapeutic use*
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Apoptosis / drug effects
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Apoptosis / genetics
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Carcinoma / drug therapy
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Carcinoma / genetics
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Carcinoma, Squamous Cell
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Head and Neck Neoplasms / drug therapy
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Head and Neck Neoplasms / genetics
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Humans
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Models, Biological
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Molecular Targeted Therapy / methods*
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Neoplasms, Squamous Cell / drug therapy
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Neoplasms, Squamous Cell / genetics
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Proto-Oncogene Proteins c-bcl-2 / antagonists & inhibitors*
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Proto-Oncogene Proteins c-bcl-2 / genetics
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Signal Transduction / drug effects
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Signal Transduction / genetics
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Squamous Cell Carcinoma of Head and Neck
Substances
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Antineoplastic Agents
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Proto-Oncogene Proteins c-bcl-2