Bcl-2 targeted-therapy for the treatment of head and neck squamous cell carcinoma

Recent Pat Anticancer Drug Discov. 2011 Jan;6(1):45-57. doi: 10.2174/157489211793980042.

Abstract

Despite recent advances in treatment of head and neck cancer, survival has not improved as expected. Bcl-2 family proteins play important role in regulating apoptosis. Recently, newer molecules have been developed for inhibition of Bcl-2 related proteins. We, herein aim to discuss the importance of Bcl-2 family proteins to the development of head and neck cancer and how the targeted-therapy for inhibition of Bcl-2 and related proteins, based on new drugs and recent patents, could improve the efficacy of the systemic therapy.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage
  • Antineoplastic Agents / therapeutic use*
  • Apoptosis / drug effects
  • Apoptosis / genetics
  • Carcinoma / drug therapy
  • Carcinoma / genetics
  • Carcinoma, Squamous Cell
  • Head and Neck Neoplasms / drug therapy
  • Head and Neck Neoplasms / genetics
  • Humans
  • Models, Biological
  • Molecular Targeted Therapy / methods*
  • Neoplasms, Squamous Cell / drug therapy
  • Neoplasms, Squamous Cell / genetics
  • Proto-Oncogene Proteins c-bcl-2 / antagonists & inhibitors*
  • Proto-Oncogene Proteins c-bcl-2 / genetics
  • Signal Transduction / drug effects
  • Signal Transduction / genetics
  • Squamous Cell Carcinoma of Head and Neck

Substances

  • Antineoplastic Agents
  • Proto-Oncogene Proteins c-bcl-2