Abstract
Cell proliferation of endometrial stromal cells treated with peritoneal fluid of women (aged 25 to 43 years) with endometriosis (n = 12) statistically significantly increased compared with the control treatment (peritoneal fluid of women without endometriosis, n = 8). Also, COX-2 gene expression and prostaglandin E(2) production were induced in those cells by increasing COX-2 promoter transcription activity, which could be attenuated by a specific p38MAPK inhibitor, suggesting a role for peritoneal fluid in the etiopathogenesis of endometriosis.
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Adult
-
Ascitic Fluid / pathology
-
Ascitic Fluid / physiology*
-
Cell Proliferation* / drug effects
-
Cells, Cultured
-
Culture Media, Conditioned / pharmacology
-
Cyclooxygenase 2 / genetics*
-
Cyclooxygenase 2 / metabolism
-
Endometriosis / pathology*
-
Endometrium / cytology
-
Endometrium / drug effects
-
Endometrium / metabolism
-
Endometrium / physiology*
-
Female
-
Gene Expression Regulation, Enzymologic / drug effects
-
Humans
-
Peritoneal Diseases / pathology*
-
Prostaglandins / metabolism
-
Stromal Cells / drug effects
-
Stromal Cells / metabolism
-
Stromal Cells / physiology*
-
Up-Regulation / drug effects
Substances
-
Culture Media, Conditioned
-
Prostaglandins
-
Cyclooxygenase 2