Candidate gene association study of magnetic resonance imaging-based hip osteoarthritis (OA): evidence for COL9A2 gene as a common predisposing factor for hip OA and lumbar disc degeneration

J Rheumatol. 2011 Apr;38(4):747-52. doi: 10.3899/jrheum.100080. Epub 2010 Dec 15.

Abstract

Objective: To study whether gene variants associated with lumbar disc degeneration (LDD) phenotypes are also associated with hip osteoarthritis (OA).

Methods: Magnetic resonance imaging (MRI)-based hip OA changes for 345 twins were assessed and 99 single-nucleotide polymorphisms (SNP) were analyzed.

Results: Variants in the COL9A2 (rs7533552, p = 0.0025) and COL10A1 (rs568725, p = 0.002) genes showed association with hip OA.

Conclusion: The associating G allele in COL9A2 changes a glutamine to arginine or to tryptophan and may predispose to both hip OA and LDD, making it a candidate for degenerative connective tissue diseases.

MeSH terms

  • Adult
  • Aged
  • Collagen Type IX / genetics*
  • Genetic Predisposition to Disease*
  • Humans
  • Intervertebral Disc Degeneration* / genetics
  • Intervertebral Disc Degeneration* / pathology
  • Lumbar Vertebrae / pathology*
  • Magnetic Resonance Imaging / methods
  • Middle Aged
  • Osteoarthritis, Hip* / genetics
  • Osteoarthritis, Hip* / pathology
  • Polymorphism, Single Nucleotide*
  • Twin Studies as Topic

Substances

  • COL9A2 protein, human
  • Collagen Type IX