[The changes of estrogen receptor (ER) and progesterone receptor (PR) mRNAs in endometrium with endometriosis]

Zhongguo Ying Yong Sheng Li Xue Za Zhi. 2004 May;20(2):194-6.
[Article in Chinese]

Abstract

Aim: To explore the expression of ER and PR mRNAs in endometrium with endometriosis.

Methods: The rat model of endometriosis was established, and the expression of ER, PR mRNAs in the endometrium was examined by reverse transcription-polymerase chain reaction (RT-PCR).

Results: The expression of ER and PR mRNAs in ectopic endometrium was significantly lower than that in eutopic and normal endometrium (P < 0.01). But no difference was observed between eutopic and normal endometrium (P > 0.05). Ratio of ER/PR mRNA in ectopic endometrium was larger than that in eutopic and in normal endometrium (P < 0.01).

Conclusion: The result illuminates that the increased ER plays a vital role in the onset of endometriosis.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Endometriosis / metabolism*
  • Endometrium / metabolism*
  • Female
  • RNA, Messenger / genetics
  • Rats
  • Rats, Sprague-Dawley
  • Receptors, Estrogen / genetics
  • Receptors, Estrogen / metabolism*
  • Receptors, Progesterone / genetics
  • Receptors, Progesterone / metabolism*

Substances

  • RNA, Messenger
  • Receptors, Estrogen
  • Receptors, Progesterone