The interleukin 10 promoter haplotype ACA and the long-form variant of the DRD4 uVNTR polymorphism are associated with vulnerability to schizophrenia

Psychiatry Res. 2011 Jul 30;188(2):294-6. doi: 10.1016/j.psychres.2010.12.025. Epub 2011 Jan 8.

Abstract

A total of 934 patients with schizophrenia and 433 controls were genotyped for the interleukin-10 (IL-10) promoter and DRD4 uVNTR polymorphisms. DRD4 long-form variants (namely, those with ≥5 repeats), homozygosity for the 4-repeat allele, and the IL-10 haplotype ACA were associated with schizophrenia, respectively. No obvious interactions among the potential polymorphisms were found, which suggests that IL-10 and DRD4 confer vulnerability to schizophrenia independently.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cohort Studies
  • Female
  • Genetic Predisposition to Disease*
  • Genome-Wide Association Study
  • Genotype
  • Humans
  • Interleukin-10 / genetics*
  • Male
  • Minisatellite Repeats / genetics*
  • Models, Genetic
  • Polymorphism, Genetic / genetics*
  • Promoter Regions, Genetic / genetics*
  • Receptors, Dopamine D4 / genetics*
  • Schizophrenia / genetics*
  • Taiwan

Substances

  • DRD4 protein, human
  • IL10 protein, human
  • Interleukin-10
  • Receptors, Dopamine D4