c-Maf suppresses human T-cell leukemia virus type 1 Tax by competing for CREB-binding protein

Cancer Sci. 2011 Apr;102(4):890-4. doi: 10.1111/j.1349-7006.2011.01873.x. Epub 2011 Feb 15.

Abstract

Latent infection of human T-cell leukemia virus type 1 (HTLV-1) is considered to be preferentially associated with CCR4(+) CD4(+) T cells. Here we report that c-Maf, one of the critical transcription factors for Th2 differentiation, suppresses the transcriptional activity of HTLV-1 Tax by competing for CREB-binding protein. Notably, c-maf expression is selectively induced in a fraction of CCR4(+) CD4(+) T cells upon activation. Furthermore, c-Maf significantly decreases Tax-induced HTLV-1 envelope gp46 gene expression from an infectious HTLV-1 molecular clone and tax expression in a cell-free HTLV-1 infection system. Collectively, c-Maf may play a role in latent infection of HTLV-1 in CCR4(+) CD4(+) T cells by negatively regulating Tax activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blotting, Western
  • CD4-Positive T-Lymphocytes / metabolism
  • CD4-Positive T-Lymphocytes / virology
  • CREB-Binding Protein / genetics
  • CREB-Binding Protein / metabolism*
  • Cell Transformation, Viral
  • Gene Products, env / genetics
  • Gene Products, env / metabolism
  • Gene Products, tax / antagonists & inhibitors
  • Gene Products, tax / genetics
  • Gene Products, tax / metabolism*
  • HTLV-I Infections / genetics
  • HTLV-I Infections / metabolism*
  • HTLV-I Infections / virology
  • Human T-lymphotropic virus 1 / genetics
  • Human T-lymphotropic virus 1 / metabolism*
  • Humans
  • Jurkat Cells
  • Leukemia-Lymphoma, Adult T-Cell / genetics
  • Leukemia-Lymphoma, Adult T-Cell / metabolism
  • Leukemia-Lymphoma, Adult T-Cell / virology
  • Luciferases / metabolism
  • Promoter Regions, Genetic
  • Proto-Oncogene Proteins c-maf / antagonists & inhibitors
  • Proto-Oncogene Proteins c-maf / genetics
  • Proto-Oncogene Proteins c-maf / metabolism*
  • RNA, Messenger / genetics
  • RNA, Small Interfering / genetics
  • Receptors, CCR4 / genetics
  • Receptors, CCR4 / metabolism
  • Retroviridae Proteins, Oncogenic / genetics
  • Retroviridae Proteins, Oncogenic / metabolism
  • Reverse Transcriptase Polymerase Chain Reaction
  • Th2 Cells
  • Transcriptional Activation
  • Virion

Substances

  • CCR4 protein, human
  • Gene Products, env
  • Gene Products, tax
  • MAF protein, human
  • Proto-Oncogene Proteins c-maf
  • RNA, Messenger
  • RNA, Small Interfering
  • Receptors, CCR4
  • Retroviridae Proteins, Oncogenic
  • gp46 protein, Human T-cell leukemia virus type I
  • Luciferases
  • CREB-Binding Protein
  • CREBBP protein, human