Effect of GnRH agonist and hCG treatment on VEGF, angiopoietin-2, and VE-cadherin: trying to explain the link to ovarian hyperstimulation syndrome

María Cerrillo; Alberto Pacheco; Sara Rodríguez; Raúl Gómez; Francisco Delgado; Antonio Pellicer; Juan A Garcia-Velasco

doi:10.1016/j.fertnstert.2010.12.054

Effect of GnRH agonist and hCG treatment on VEGF, angiopoietin-2, and VE-cadherin: trying to explain the link to ovarian hyperstimulation syndrome

Fertil Steril. 2011 Jun 30;95(8):2517-9. doi: 10.1016/j.fertnstert.2010.12.054. Epub 2011 Jan 26.

Authors

María Cerrillo¹, Alberto Pacheco, Sara Rodríguez, Raúl Gómez, Francisco Delgado, Antonio Pellicer, Juan A Garcia-Velasco

Affiliation

¹ IVI-Madrid, Rey Juan Carlos University, Madrid, Spain.

PMID: 21269615
DOI: 10.1016/j.fertnstert.2010.12.054

Abstract

This study evaluated the differentially modulated expression of vascular mediators in oocyte donors after hCG vs. GnRHa triggering, trying to understand ovarian hyperstimulation syndrome pathophysiology. Donors who received GnRH agonist triggering showed a statistically significant decrease in vascular endothelial growth factor in follicular fluid and in mRNA expression in granulosa cells, with no differences in angiopoietin 2 and vascular endothelial cadherin levels in serum or follicular fluid. This differential regulation of vascular endothelial growth factor by hCG might explain the higher likelihood of ovarian hyperstimulation syndrome following hCG administration compared with GnRH agonists.

Publication types

Comparative Study

MeSH terms

Angiopoietin-2 / analysis*
Angiopoietin-2 / genetics
Antigens, CD / analysis*
Antigens, CD / genetics
Cadherins / analysis*
Cadherins / genetics
Chorionic Gonadotropin / administration & dosage*
Chorionic Gonadotropin / adverse effects
Enzyme-Linked Immunosorbent Assay
Female
Fertility Agents, Female / administration & dosage*
Fertility Agents, Female / adverse effects
Follicular Fluid / chemistry
Gonadotropin-Releasing Hormone / agonists*
Granulosa Cells / chemistry
Humans
Oocyte Donation
Ovarian Hyperstimulation Syndrome / etiology
Ovarian Hyperstimulation Syndrome / genetics
Ovarian Hyperstimulation Syndrome / metabolism*
Ovulation Induction / adverse effects
Ovulation Induction / methods*
Pregnancy
Prospective Studies
RNA, Messenger / analysis
Reverse Transcriptase Polymerase Chain Reaction
Spain
Triptorelin Pamoate / administration & dosage*
Triptorelin Pamoate / adverse effects
Vascular Endothelial Growth Factor A / analysis*
Vascular Endothelial Growth Factor A / genetics

Substances

Angiopoietin-2
Antigens, CD
Cadherins
Chorionic Gonadotropin
Fertility Agents, Female
RNA, Messenger
VEGFA protein, human
Vascular Endothelial Growth Factor A
cadherin 5
Triptorelin Pamoate
Gonadotropin-Releasing Hormone