Commentary. A picture of Mitf in melanoma immortality

C R Goding

doi:10.1038/onc.2010.641

Commentary. A picture of Mitf in melanoma immortality

Oncogene. 2011 May 19;30(20):2304-6. doi: 10.1038/onc.2010.641. Epub 2011 Jan 31.

Author

C R Goding¹

Affiliation

¹ Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Headington, Oxford, UK.

PMID: 21278792
DOI: 10.1038/onc.2010.641

Abstract

The Mitf gene has a key role in melanocytes and melanoma by regulating cell cycle progression, survival and differentiation. Two papers in this issue of Oncogene (Cheli et al., 2011; Strub et al., 2011) reveal that low-Mitf cells can initiate tumors with high efficiency, and that Mitf blocks senescence by regulating genes implicated in S-phase progression and mitosis.

Publication types

Comment

MeSH terms

Cell Cycle / genetics
Cell Differentiation / genetics
Cellular Senescence / genetics*
Gene Expression Regulation, Neoplastic
Humans
Melanocytes / metabolism
Melanoma / genetics*
Melanoma / mortality
Microphthalmia-Associated Transcription Factor / genetics*
Neoplastic Stem Cells / physiology
Skin Neoplasms / genetics*
Skin Neoplasms / mortality

Substances

MITF protein, human
Microphthalmia-Associated Transcription Factor