Age at onset in bipolar disorder: Investigation of the role of TaqIA polymorphism of DRD2 gene in a Sardinian sample

A Squassina; M Manchia; M Costa; C Chillotti; R Ardau; M Del Zompo; G Severino

doi:10.1016/j.eurpsy.2010.09.013

Age at onset in bipolar disorder: Investigation of the role of TaqIA polymorphism of DRD2 gene in a Sardinian sample

Eur Psychiatry. 2011 Apr;26(3):141-3. doi: 10.1016/j.eurpsy.2010.09.013. Epub 2011 Feb 2.

Authors

A Squassina¹, M Manchia, M Costa, C Chillotti, R Ardau, M Del Zompo, G Severino

Affiliation

¹ Laboratory of Molecular Genetics, Section of Clinical Pharmacology, Department of Neuroscience B.B. Brodie, University of Cagliari, Sp 8, Sestu-Monserrato, Cagliari, Italy. squassina@unica.it

PMID: 21292452
DOI: 10.1016/j.eurpsy.2010.09.013

Abstract

Bipolar disorder (BD) is a highly heterogeneous and heritable psychiatric illness. Age at onset has been shown to be a powerful tool for dissecting both the phenotypic and genetic complexity of BD. In this article, we present findings from an association study between the DRD2 TaqIA polymorphism and age at onset, showing that both alleles and genotypes at this locus associate with early onset BD.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Age of Onset
Alleles
Bipolar Disorder / epidemiology*
Bipolar Disorder / genetics*
Female
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
Humans
Italy / epidemiology
Male
Middle Aged
Polymorphism, Single Nucleotide*
Receptors, Dopamine D2 / genetics*

Substances

Receptors, Dopamine D2