Abstract
a recent study in a mouse model of colitis has demonstrated that interleukin (Il)‑13, through inhibition of the mixed type 1 and type 17 T‑helper cell inflammatory response, has a protective effect. the decoyreceptor Il‑13rα2 inhibits this protective effect, suggesting blockade of Il‑13rα2 as a potential therapy for patients with IBD.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects
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Colitis / chemically induced
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Colitis / metabolism*
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Colitis / pathology*
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Disease Models, Animal
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Humans
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Interferon-gamma / metabolism
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Interleukin-13 / metabolism*
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Interleukin-13 Receptor alpha2 Subunit / deficiency*
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Interleukin-13 Receptor alpha2 Subunit / genetics
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Interleukin-17 / metabolism
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Mice
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Mice, Knockout
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Piroxicam / adverse effects
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T-Lymphocytes, Helper-Inducer / pathology*
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Interleukin-13
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Interleukin-13 Receptor alpha2 Subunit
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Interleukin-17
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Piroxicam
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Interferon-gamma