Urine alkalinization may be enough for the treatment of bilateral renal pelvis stones associated with Lesch-Nyhan syndrome

Mi Mi Oh; Byeong Kuk Ham; Seok Ho Kang; Jae Hyun Bae; Je Jong Kim; Ki Hwan Yoo; Duck Ki Yoon; Du Geon Moon

doi:10.1007/s00240-011-0364-z

Urine alkalinization may be enough for the treatment of bilateral renal pelvis stones associated with Lesch-Nyhan syndrome

Urol Res. 2011 Oct;39(5):417-9. doi: 10.1007/s00240-011-0364-z. Epub 2011 Feb 18.

Authors

Mi Mi Oh¹, Byeong Kuk Ham, Seok Ho Kang, Jae Hyun Bae, Je Jong Kim, Ki Hwan Yoo, Duck Ki Yoon, Du Geon Moon

Affiliation

¹ Department of Urology, Korea University Hospital, 80, Guro-dong, Guro-ku, Seoul 152-703, Republic of Korea.

PMID: 21331772
DOI: 10.1007/s00240-011-0364-z

Abstract

Lesch-Nyhan syndrome is a rare sex-linked disorder of purine metabolism that is caused by a mutation in the hypoxanthine-guanine phosphoribosyltransferase (HPRT) gene which causes marked hyperuricemia and hyperuricosuria, with signs of gouty arthritis and uric acid stone disease in early childhood. We report a case of renal pelvis calculi which was dissolved within 10 days of urine alkalinization and hydration.

Publication types

Case Reports

MeSH terms

Allopurinol / therapeutic use
Child
Fluid Therapy
Humans
Hydrogen-Ion Concentration
Hypoxanthine Phosphoribosyltransferase / genetics
Kidney Calculi / diagnostic imaging
Kidney Calculi / etiology*
Kidney Calculi / therapy*
Kidney Calculi / urine
Kidney Pelvis
Lesch-Nyhan Syndrome / complications*
Lesch-Nyhan Syndrome / genetics
Male
Mutation
Tomography, X-Ray Computed
Urine / chemistry

Substances

Allopurinol
Hypoxanthine Phosphoribosyltransferase