Single nucleotide polymorphisms and mRNA expression for melatonin MT(2) receptor in depression

Elżbieta Gałecka; Janusz Szemraj; Antoni Florkowski; Piotr Gałecki; Małgorzata Bieńkiewicz; Małgorzata Karbownik-Lewińska; Andrzej Lewiński

doi:10.1016/j.psychres.2011.01.021

Single nucleotide polymorphisms and mRNA expression for melatonin MT(2) receptor in depression

Psychiatry Res. 2011 Oct 30;189(3):472-4. doi: 10.1016/j.psychres.2011.01.021. Epub 2011 Feb 26.

Authors

Elżbieta Gałecka¹, Janusz Szemraj, Antoni Florkowski, Piotr Gałecki, Małgorzata Bieńkiewicz, Małgorzata Karbownik-Lewińska, Andrzej Lewiński

Affiliation

¹ Department of Endocrinology and Metabolic Diseases, Medical University of Łódź, Poland.

PMID: 21353709
DOI: 10.1016/j.psychres.2011.01.021

Abstract

Polymorphisms (rs 4753426 and rs 794837) and expression of the melatonin MT(2) receptor gene were evaluated in 181 patients with recurrent depressive disorder (rDD) and 149 healthy subjects of Polish origin. We found an increased risk for rDD in patients with the C allele and a decreased risk in patients with the T allele (rs4753426). Patients with the AT heterozygote (rs794837) had an increased mRNA level. The significance of the MT(2) receptor gene and the risk of rDD are suggested.

MeSH terms

Adult
Depression / genetics*
Female
Gene Frequency
Genetic Predisposition to Disease*
Genome-Wide Association Study
Genotype
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide / genetics*
RNA, Messenger / metabolism*
Receptor, Melatonin, MT2 / genetics*
Statistics, Nonparametric

Substances

RNA, Messenger
Receptor, Melatonin, MT2